Where & When
The story is set on the planet Vortis, which is specifically stated to be in a galaxy beyond our own. In the final episode, the Animus talks about humans as if it knows what they are, and where they come from, which implies a far future setting when humanity has at least reached beyond our own galaxy. However, there is no way to be more precise than this, and it’s also possible from the context that it has only recently gained this information from its prisoners (it’s trying to read their minds at the time) so we can’t even be confident of that much. Not that it’s likely to matter in most games.

